Genomic diversity of antimicrobial resistance in non-typhoidal Salmonella in Victoria, Australia

CM Sia; SL Baines; M Valcanis; DYJ Lee; A Gonçalves da Silva; SA Ballard; M Easton; T Seemann; BP Howden; DJ Ingle; DA Williamson

Journal article

Genomic diversity of antimicrobial resistance in non-typhoidal Salmonella in Victoria, Australia

CM Sia, SL Baines, M Valcanis, DYJ Lee, A Gonçalves da Silva, SA Ballard, M Easton, T Seemann, BP Howden, DJ Ingle, DA Williamson

Microbial Genomics | Published : 2021

DOI: 10.1099/MGEN.0.000725

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Abstract

Non-typhoidal Salmonella (NTS) is the second most common cause of foodborne bacterial gastroenteritis in Australia with antimicrobial resistance (AMR) increasing in recent years. Whole-genome sequencing (WGS) provides opportunities for in silico detection of AMR determinants. The objectives of this study were two-fold: (1) establish the utility of WGS analyses for inferring phenotypic resistance in NTS, and (2) explore clinically relevant genotypic AMR profiles to third generation cephalosporins (3GC) in NTS lineages. The concordance of 2490 NTS isolates with matched WGS and phenotypic susceptibility data against 13 clinically relevant antimicrobials was explored. In silico serovar predictio..

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University of Melbourne Researchers

Sarah Baines Author

Torsten Seemann Author

Ben Howden Author

Danielle Ingle Author

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Grants

Awarded by State Government of Victoria

Funding Acknowledgements

The Microbiological Diagnostic Unit Public Health Laboratory is funded by the Victorian Government. This work was supported by a National Health and Medical Research Council (NHMRC) , Australia Project Grant (APP1129770) and Partnership Grant (APP1149991) . D.A.W. is supported by an NHMRC Investigator Grant (GNT1174555) . D.J.I. was supported by a National Health and Medical Research Council (NHMRC) Emerging Leadership Fellowship (GNT1195210) . B.P.H. was supported by NHMRC Leadership Fellowship (GNT1196103) .